Tonichem Pharmaceutical Technology Co., Limited

Celebrate Tonichem successed to enlarge manufacture art of 
(R)-3-Piperidinamine dihydrochloride and (R)-3-(Boc-Amino)piperidine

DPP-4 inhibitors are a class of oral hypoglycemics that block DPP-4. They can be used to treat diabetes mellitus type 2. There are two important new drugs of DPP-4 inhibitors, Linagliptin and Alogliptin.
 

(R)-3-Piperidinamine is the key intermediate of both of Linagliptin and Alogliptin. We usually use (R)-3-Piperidinamine dihydrochloride [334618-23-4] or (R)-3-(Boc-Amino)piperidine [309956-78-3] to synthesis these two APIs.
 

 
After several months’ effort, our R&D and manufacture department success to enlarge our manufacture art of these two intermediates to 400kg each batch. What is more, the products’ quality is very outstanding. Both of their purity and ee are more than 99%.
 

We hope our effort can help our customers to cut down their cost of  APIs. And patience can purchase them at a lower price.